Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis
نویسندگان
چکیده
منابع مشابه
EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis.
OBJECTIVE To compare the efficacy and side effects of intermittent pulse cyclophosphamide plus methylprednisolone with continuous oral cyclophosphamide plus prednisolone, followed by azathioprine, in patients with proliferative glomerulonephritis caused by systemic lupus erythematosus (SLE). METHODS A multicentre randomised controlled trial was conducted between June 1992 and May 1996 involvi...
متن کاملCOMBINATION THERAPY WITH PULSE CYCLOPHOSPHAMIDE PLUS CORTICOSTEROIDS IMPROVES RENAL OUTCOME IN PATIENTS WITH LUPUS NEPHRITIS
ABSTRACT Background: The prognosis of SLE is int1uenced by the onset of glomerulonephtitis. Clinical ttials in lupus nephritis have demonstrated that cyclophosphamide therapy is the superior regimen in the management oflupus nephritis for preserving renal function. Objective: The purpose of this study is to define the outcome of renal function with bolus pu lses of cyclophosphamide and steroid...
متن کاملMega-dose methylprednisolone versus pulse methylprednisolone.
Although the main hematologic findings, such as spherocytosis, polychromasia, anisopoikilocytosis, and reticulocytosis, etc. and Coombs test results were not given, the patient most likely had hemolytic anemia, for which he was given pulse methylprednisolone (MP) three days after intravenous immunoglobulin (IVIG) therapy, which might also cause encephalopathy. However, the hematologic changes w...
متن کاملintravenous pulse cyclophosphamide treatment of lupus nephritis: a retrospective ten years study
nephritis remains an important problem in patients with systemic lupus erythematosus (sle). we conducted retrospective study to evaluate the efficiency of intravenous pulse cyclophosphamide in lupus nephritis: from 1983 to 1993, we reviewed 133 patients with biopsy proven lupus nephritis, 47 of them excluded because of short period of follow-up or defective laboratory data. eighty six patients ...
متن کاملcombination therapy with pulse cyclophosphamide plus corticosteroids improves renal outcome in patients with lupus nephritis
abstract background: the prognosis of sle is int1uenced by the onset of glomerulonephtitis. clinical ttials in lupus nephritis have demonstrated that cyclophosphamide therapy is the superior regimen in the management oflupus nephritis for preserving renal function. objective: the purpose of this study is to define the outcome of renal function with bolus pu lses of cyclophosphamide and steroid ...
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ژورنال
عنوان ژورنال: The Lancet
سال: 1992
ISSN: 0140-6736
DOI: 10.1016/0140-6736(92)92292-n